解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It is well established that +ssRNA viruses manipulate cellular lipid homoeostasis and distribution to facilitate efficient replication. Here, we show that the cellular lipid ceramide is redistributed to the West Nile virus strain Kunjin virus (WNVKUN) replication complex (RC) but not to the dengue virus serotype 2 str...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.06.015
更新日期:2015-10-01 00:00:00
abstract::The Epstein-Barr virus (EBV) predominantly establishes a latent infection in B lymphocytes, and occasionally switches from the latent state to the lytic cycle. In this report, we identified and examined the role of a lytic gene, BRRF2. We first prepared an antibody against BRRF2 and identified the gene product as a vi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.05.010
更新日期:2015-10-01 00:00:00
abstract::Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.05.003
更新日期:2015-09-01 00:00:00
abstract::Herpes simplex virus 1 (HSV-1) infection induces changes to the host cell nucleus including relocalization of the cellular protein Upstream Binding Factor (UBF) from the nucleolus to viral replication compartments (VRCs). Herein, we tested the hypothesis that UBF is recruited to VRCs to promote viral DNA replication. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.04.003
更新日期:2015-09-01 00:00:00
abstract::Our recent results demonstrated that bile acids facilitate virus escape from the endosomes into the cytoplasm for successful replication of porcine enteric calicivirus (PEC). We report a novel finding that bile acids can be substituted by cold treatment for endosomal escape and virus replication. This endosomal escape...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.04.022
更新日期:2015-09-01 00:00:00
abstract::Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucose-3/4 sites were lo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.04.006
更新日期:2015-09-01 00:00:00
abstract::Exosomes are membranous extracellular nanovesicles secreted by diverse cell types. Exosomes from healthy human semen have been shown to inhibit HIV-1 replication and to impair progeny virus infectivity. In this study, we examined the ability of healthy human semen exosomes to restrict HIV-1 and LP-BM5 murine AIDS viru...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.03.040
更新日期:2015-08-01 00:00:00
abstract::Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. In Europe, West Nile virus (WNV) outbreaks have dramatically increased in number and severity in recent years, with dozens of human and horse deaths and a high avian mortality across the continent. Besides WNV, the only ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.03.020
更新日期:2015-08-01 00:00:00
abstract::The minute virus of mice, prototype strain (MVMp), is a non-enveloped, single-stranded DNA virus of the family Parvoviridae. Unlike other parvoviruses, the mechanism of cellular uptake of MVMp has not been studied in detail. We analyzed MVMp endocytosis in mouse LA9 fibroblasts and a tumor cell line derived from epith...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.02.054
更新日期:2015-08-01 00:00:00
abstract::Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.02.042
更新日期:2015-07-01 00:00:00
abstract::The roles of two porcine circovirus replication initiator proteins, Rep and Rep׳, in generating copy-release and rolling-circle DNA replication intermediates were determined. Rep uses the supercoiled closed-circular genome (ccc) to initiate leading-strand synthesis (identical to copy-release replication) and generates...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.01.004
更新日期:2015-07-01 00:00:00
abstract::Virus genomes are condensed and packaged inside stable proteinaceous capsids that serve to protect them during transit from one cell or host organism, to the next. During virus entry, capsid shells are primed and disassembled in a complex, tightly-regulated, multi-step process termed uncoating. Here we compare the unc...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2015.01.024
更新日期:2015-05-01 00:00:00
abstract::To celebrate the sixtieth anniversary of Virology a survey is made of the plant viruses, virologists and their institutions, and tools and technology described in the first decade of plant virus publications in Virology. This was a period when plant viruses increasingly became tools of discovery as epistemic objects a...
journal_title:Virology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.virol.2015.03.019
更新日期:2015-05-01 00:00:00
abstract::Studies of the cellular autophagy pathway have exploded over the past twenty years. Now appreciated as a constitutive degradative mechanism that promotes cellular homeostasis, autophagy is also required for a variety of developmental processes, cellular stress responses, and immune pathways. Autophagy certainly acts a...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2015.03.042
更新日期:2015-05-01 00:00:00
abstract::The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation. Many viruses have evolved mechanisms to manipulate this signaling pathway to ensure successful virus replication. The human herpesvirus...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2015.02.040
更新日期:2015-05-01 00:00:00
abstract::H7N9 influenza A first caused human infections in early 2013 in China. Virus genetics, histories of patient exposures to poultry, and previous experimental studies suggest the source of the virus is a domestic avian species, such as chickens. In order to better understand the ecology of this H7N9 in chickens, we evalu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.01.013
更新日期:2015-03-01 00:00:00
abstract::Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prp(sc), thought to be the causative agent of variant a Creutzfeldt-Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen in HIV-1 infection. In the pre...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.11.032
更新日期:2015-02-01 00:00:00
abstract::The P1a protein of the ipomovirus Cucumber vein yellowing virus is one of the self-cleavage serine proteases present in Potyviridae family members. P1a is located at the N-terminal end of the viral polyprotein, and is closely related to potyviral P1 protease. For its proteolytic activity, P1a requires a still unknown ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.12.013
更新日期:2015-02-01 00:00:00
abstract::Cauliflower mosaic virus gene VI product (P6) is an essential protein that forms cytoplasmic, inclusion bodies (IBs). P6 contains four regions involved in self-association, termed D1-D4. D3 binds to D1, along with D4 and contains a spacer region (termed D3b) between two RNA-binding domains. Here we show D3b binds full...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.11.017
更新日期:2015-02-01 00:00:00
abstract::Genetic variants surrounding the interferon-λ3 (IFNL3) gene are strongly associated with clearance of hepatitis C virus (HCV). A variant (rs368234815 TT/ΔG) upstream of IFNL3 was recently implicated to control expression of a novel gene termed IFNL4. We conducted genetic analysis of rs368234815 in a chronic HCV patien...
journal_title:Virology
pub_type: 临床试验,杂志文章
doi:10.1016/j.virol.2014.12.020
更新日期:2015-02-01 00:00:00
abstract::Marek's disease virus (MDV) is a representative alpha herpes virus able to induce rapid-onset T-cell lymphoma in its natural host and regarded as an ideal model for the study of virus-induced tumorigenesis. Recent studies have shown that the mdv1-miR-M4-5p, a viral analog of cellular miR-155, is critical for MDV׳s onc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.11.027
更新日期:2015-02-01 00:00:00
abstract::Tetherin has been defined as a restriction factor of HIV-1 and several other enveloped viruses. However, the significance of tetherin in viral infection remains to be further addressed. Here, we investigated whether tetherin plays a role in HSV-2 infection. Our study revealed that overexpression of tetherin restricted...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.11.005
更新日期:2015-01-15 00:00:00
abstract::We have validated a flexible, high-throughput and relatively inexpensive RT-QPCR array platform for absolute quantification of Epstein-Barr virus transcripts in different latent and lytic infection states. Several novel observations are reported. First, during infection of normal B cells, Wp-initiated latent gene tran...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.10.030
更新日期:2015-01-01 00:00:00
abstract::Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl ra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.10.017
更新日期:2015-01-01 00:00:00
abstract::Middle East respiratory syndrome coronavirus (MERS-CoV) infects host cells through binding the receptor binding domain (RBD) on its spike glycoprotein to human receptor dipeptidyl peptidase 4 (hDPP4). Here, we report identification of critical residues on hDPP4 for RBD binding and virus entry through analysis of a pan...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.10.006
更新日期:2014-12-01 00:00:00
abstract::Entry determinants in the XPR1 receptor for the xenotropic/polytropic mouse leukemia viruses (XP-MLVs) lie in its third and fourth putative extracellular loops (ECLs). The critical ECL3 receptor determinant overlies a splice donor and is evolutionarily conserved in vertebrate XPR1 genes; 2 of the 3 rare replacement mu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.049
更新日期:2014-11-01 00:00:00
abstract::Lloviu virus (LLOV), a phylogenetically divergent filovirus, is the proposed etiologic agent of die-offs of Schreibers's long-fingered bats (Miniopterus schreibersii) in western Europe. Studies of LLOV remain limited because the infectious agent has not yet been isolated. Here, we generated a recombinant vesicular sto...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.08.019
更新日期:2014-11-01 00:00:00
abstract::Superinfection exclusion (SIE), a phenomenon in which a preexisting viral infection prevents a secondary infection with the same or closely related virus, has been described for different viruses, including important pathogens of humans, animals, and plants. Several mechanisms acting at various stages of the viral lif...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.08.031
更新日期:2014-11-01 00:00:00
abstract::The 5' leader region of the HIV-1 RNA contains the major 5' splice site (ss) that is used in the production of all spliced viral RNAs. This splice-donor (SD) region can fold a stem-loop structure. We demonstrate that whereas stabilization of this SD hairpin reduces splicing efficiency, destabilization increases splici...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.09.018
更新日期:2014-11-01 00:00:00
abstract::Feline morbillivirus (FmoPV) has recently been identified in Hong Kong and Japan. FmoPV is considered to belong to the genus Morbillivirus, in the family Paramyxoviridae. In this study, the complete nucleotide sequences of three strains of FmoPV detected in cats in Japan were determined. Among the six genes in FmoPV; ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.09.003
更新日期:2014-11-01 00:00:00
abstract::The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nucl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.08.014
更新日期:2014-11-01 00:00:00
abstract::The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8(+) T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.09.004
更新日期:2014-11-01 00:00:00
abstract::Progressive Multifocal Leukoencephalopathy (PML) is caused by lytic replication of JC virus (JCV) in specific cells of the central nervous system. Like other polyomaviruses, JCV encodes a large T-antigen helicase needed for replication of the viral DNA. Here, we report the development of a luciferase-based, quantitati...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.042
更新日期:2014-11-01 00:00:00
abstract::Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.039
更新日期:2014-11-01 00:00:00
abstract::Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.023
更新日期:2014-09-01 00:00:00
abstract::Human parainfluenza virus type 1 (hPIV1) and type 3 (hPIV3) initiate infection by sialic acid binding. Here, we investigated sialic acid linkage specificities for binding and infection of hPIV1 and hPIV3 by using sialic acid linkage-modified cells treated with sialidases or sialyltransferases. The hPIV1 is bound to on...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.033
更新日期:2014-09-01 00:00:00
abstract::Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controllin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.018
更新日期:2014-09-01 00:00:00
abstract::Pre-exposure prophylaxis (PrEP) strategies utilizing anti-retroviral drugs show considerable promise for HIV prevention. However there is insufficient pharmacokinetic (PK) data on drug concentrations required for protection at the relevant mucosal tissues where the infection is initiated. Here we evaluated the utility...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.008
更新日期:2014-09-01 00:00:00
abstract::Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GV...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.06.007
更新日期:2014-08-01 00:00:00
abstract::Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important health burden worldwide. MicroRNA122 (miR122), a liver-specific microRNA (miRNA), positively regulates HCV replication, and systemic application of antisense oligonucleotid...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.024
更新日期:2014-08-01 00:00:00